Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins
Protein ubiquitination plays an important role in regulating the abundance and conformation
of a broad range of eukaryotic proteins. This process involves a cascade of enzymes
including ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and
ubiquitin ligases (E3). E1 and E2 represent two families of structurally related proteins and
are relatively well characterized. In contrast, the nature and mechanism of E3, proposed to
contain activities in catalyzing isopeptide bond formation (ubiquitin ligation) and substrate …
of a broad range of eukaryotic proteins. This process involves a cascade of enzymes
including ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and
ubiquitin ligases (E3). E1 and E2 represent two families of structurally related proteins and
are relatively well characterized. In contrast, the nature and mechanism of E3, proposed to
contain activities in catalyzing isopeptide bond formation (ubiquitin ligation) and substrate …
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